The PACIFIC study is testing how well baxdrostat with dapagliflozin work together in adults with chronic kidney disease and high blood pressure
About the study
Status: Enrolling now
Condition: Chronic Kidney Disease (CKD)
Study treatments: baxdrostat and dapagliflozin
Key criteria
Reduced kidney function
Taking medication to lower blood pressure- either an ACE inhibitor* or ARB*
Not on dialysis treatment
Age: 18 years and older
Sex: all
(*angiotensin-converting enzyme, angiotensin 2 receptor blocker)
Study details
Participation length: Up to 5 years
Number of visits: Up to 24
Phase: 3
Potential placebo: Yes
About
The PACIFIC study is for adults living with CKD who are taking medication to lower their blood pressure- either an ACE inhibitor (angiotensin-converting enzyme) or ARB (angiotensin 2 receptor blocker). The study is testing whether taking baxdrostat and dapagliflozin together can reduce the risks of kidney failure or serious heart problems better than taking dapagliflozin alone.
Study treatment description
What are baxdrostat and dapagliflozin?
Baxdrostat is a study medication that is being tested to see if it stops extra fluid and waste from building up in the body and reduces high blood pressure.
Dapagliflozin is a type of medication that is already approved to help people with CKD. It helps the body remove sugar from the blood through the urine and helps to slow the worsening of kidney function in CKD. You may already be taking dapagliflozin or another SGLT2 inhibitor* to treat your CKD.
Everyone in the study will receive dapagliflozin. Half the people in the study will take dapagliflozin with baxdrostat and the other half will receive dapagliflozin and a placebo*.
(*SGLT2 inhibitor (sodium–glucose cotransporter-2) is a type of treatment that helps the kidneys remove more salt and sugars from the body)
(*Placebo: a placebo looks like real medicine but has no active ingredients. Some trials use them for comparison, but many compare new and standard treatments.)
What does the study involve?
See below for a summary of the timing and key activities that will happen during this study.
Before
Up to 6 weeks
1 – 3 study doctor visits
Decide if the study is right for you
Physical exams, blood, urine and heart tests
During
Up to 5 years
Receive study treatments
13 - 21 study doctor visits
Physical exams, blood, urine and heart tests
After
Study doctor visit
Physical exams, blood, urine and heart tests